The Molise regional election of 2006 took place on 5–6 November 2006.

Incumbent Michele Iorio (Forza Italia) defeated Roberto Ruta (The Daisy).

Results Candidates & parties votes votes (%) seatsreg. list seatsprov. lists Michele Iorio111,81154.02612 Forza Italia39,61019.84→5 Union of Christian and Centre Democrats19,9359.99→2 National Alliance18,1209.08→2 Christian Democracy for Autonomies10,1035.06→1 Project Molise9,6654.84→1 Civil Molise7,4733.74→1 Pensioners' Party3850.19→0 Alternative for Molise3510.18→0 Roberto Ruta95,24645.98111 Democracy is Freedom – The Daisy24,79712.42→3 Democrats of the Left21,76610.90→3 Italy of Values17,5168.78→2 Union of Democrats for Europe10,8765.45→1 Italian Democratic Socialists6,4133.21→1 Party of Italian Communists4,4492.23→1 Communist Refoundation Party4,4422.23→0 Federation of the Greens3,7221.86→0 Total207,127100.00723 Sources: Ministry of the Interior – Historical Archive of Elections