EMD-386088 is an tetrahydropyridinylindole derivative which is used in scientific research. It acts as a potent 5-HT6 receptor partial agonist, with a Ki of 1 nM, a significantly higher affinity than older 5-HT6 agonists such as EMDT, although it possesses moderate affinity for the 5-HT3 receptor as well. Subsequent research has determined that EMD-386088 is also a dopamine reuptake inhibitor and that this action is involved in the antidepressant-like effects of the drug in rodents.
EMD-386088 can be further reacted with a butyrophenone sidechain.Genus Possanza, Kurt Freter, & Sven Luttke, (1976 to Boehringer Ingelheim GmbH).
See also Tetrahydropyridinylindole Substituted tryptamine § Related compounds 2-Methyltryptamine EMDT RU-24,969 RU-28253 ST-1936
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