VBI may refer to: Biocomplexity Institute of Virginia Tech (formerly the Virginia Bioinformatics Institute), a research organization specializing in bioinformatics, computational biology, and systems biology in Virginia, United States Value-based investing, also known as value investing, an investment paradigm that involves buying securities that appear underpriced by some form of fundamental analysis VBI Vaccines Inc. and Variation Biotechnologies, related manufacturers of vaccines Victory Bible Institute, a Christian academy headquartered in Tulsa Vertebrobasilar insufficiency, a temporary set of symptoms due to decreased blood flow (ischemia) in the posterior circulation of the brain Vertical blank interrupt, a hardware feature found in some computer systems that generate a video display vertical blanking interval, a portion of a television signal Visible Broadband Imager, part of the Daniel K. Inouye Solar Telescope