William Keen or Keene may refer to:
Entertainment William Keene (1915–1992), American TV actor Bill Keene (1927–2000), American television and radio personality William B. Keene (1925–2018), American attorney, judge and television judge Will Keen (born 1970), English actor
Other William Keen (merchant) (1680s–1754), merchant and judicial officer in the British colony of Newfoundland William Keen (cricketer) (1792–1846), English amateur cricketer William Williams Keen (1837–1932), pioneer American brain surgeon William John Keen (1873–1958), Chief Commissioner of the North-West Frontier Province of British India Bill Keen (1892–1947), American baseball player
See also William Keane (disambiguation) William Kean (1871–1954), British trade unionist