Yamaguchi may refer to:

People Yamaguchi (surname), the 14th most popular Japanese surname, including a list of people.

Places Yamaguchi Prefecture, the westernmost prefecture of Honshū island of Japan Yamaguchi (city), capital of Yamaguchi Prefecture Yamaguchi Station (Yamaguchi), a JR West railway station, located in the center of Yamaguchi-shi Shin-Yamaguchi Station, a railway station in Yamaguchi-shi (Sanyō Shinkansen line) Yamaguchi, Nagano, a village in Nagano Prefecture

Fiction Kumiko "Yankumi" Yamaguchi, the character played by Yukie Nakama in Gokusen, a Japanese TV show Yamaguchi-sensei, a doctor in the manga/anime series Fighting Spirit U.S.S. Yamaguchi, an Ambassador-class Federation starship in the Star Trek franchise Yamaguchi Digital Pets, a fictional digital pets company mentioned in Fanboy & Chum Chum Yamaguchi Tadashi, a member of the Karasuno volleyball club in the manga/anime series Haikyu!!

Other uses Yamaguchi-gumi, a yakuza group 15841 Yamaguchi, an asteroid named for the Japanese prefecture Sweden v. Yamaguchi Yamaguchi esterification, a chemical reaction Shankou (disambiguation), the Chinese equivalent