Lyles is a surname. Notable people with the surname include:
Athletes Jordan Lyles (born 1990), American baseball player Josephus Lyles (born 1998), American track and field athlete Kevin Lyles (born 1973), American track and field athlete Lenny Lyles (1936–2011), American football player Lester Lyles (American football) (born 1962), American football player Nate Lyles (born 1985), American football player Noah Lyles (born 1997), American track and field athlete Robert Lyles (born 1961), American football player Trey Lyles (born 1995), Canadian–American basketball player
Other A. C. Lyles (1918–2013), American film producer Aubrey Lyles (1883–1932), American songwriter, lyricist, and vaudeville performer Lester Lyles (born 1946), United States Air Force general
See also Lyle's flying fox, a species of flying fox Lyle's Golden Syrup, a form of inverted sugar syrup Lyles, Tennessee, an unincorporated town near Nashville, Tennessee, United States Lyles Station, Indiana, an unincorporated town in Gibson County, Indiana, United States