The 1980–81 Liga Artzit season saw Beitar Tel Aviv win the title and win promotion to Liga Leumit. Beitar Jerusalem and Maccabi Haifa were also promoted.
Hapoel Hadera, Hapoel Holon and Maccabi Herzliya were all relegated to Liga Alef.
Final table
References 1980–81 Maccabi Haifa Liga Artzit table Davar, 24.5.81, Historical Jewish Press Liga Artzit table Hadshot HaSport 24 May 1981, IFA