Cottonwood Creek may refer to:
United States California Cottonwood Creek (Encinitas) Cottonwood Creek (Inyo County, California) Cottonwood Creek (Kern County) Cottonwood Creek (Sacramento River tributary) Cottonwood Creek (San Diego County) Cottonwood Creek (San Luis Creek tributary)
Missouri Cottonwood Creek (Little Tabo Creek tributary) Cottonwood Creek (Wakenda Creek tributary)
Elsewhere Cottonwood Creek (Verdigre Creek tributary), Nebraska Cottonwood Creek (Cimarron River tributary), Oklahoma Cottonwood Creek (Guadalupe County), Texas
See also Cottonwood Creek Archeological Site (disambiguation) Cottonwood Creek Bridge (disambiguation) Cottonwood Creek Ranch Airport, Malheur County, Oregon