P100 may refer to:
Automobiles Borgward P100, a German sedan Ford P100, a car-based pickup truck SsangYong Musso Sports, a South Korean SUV Tesla Model S P100, an American sedan Tesla Model X P100, an American SUV
Aviation Bellanca P-100 Airbus, an American passenger aircraft Pottier P.100, a French civil utility aircraft Rogožarski R-100, a Yugoslav fighter trainer
Science and technology Listeria virus P100, a bacteriophage Mannan-binding lectin-associated serine protease-2, an enzyme P100, a NIOSH air filtration rating P100, an event-related brain potential; see C1 and P1 (neuroscience) DSC-P100, a Sony digital camera Tesla P100, a GPU accelerator
Ships HMAS Buccaneer (P 100), a patrol boat of the Royal Australian Navy NNS Andoni (P100), a seaward defense boat of the Nigerian Navy
Other uses Papyrus 100, a biblical manuscript Project P-100, a video game P100, a state regional road in Latvia