Possamai is originally regarded as an Italian surname. In Italian, it means Possa (rests) mai (never), which translates to "Never rests". Possamai may also be a Brazilian surname.

It can specifically refer to several people:

Adam Possamai (born 1970), Belgian-Australian sociologist and writer Agnese Possamai Stéphanie Possamaï, a French judoka

Other uses Possamai construcciones, Uruguayan constructions company