Fox 21 may refer to:
Television stations in the United States: WHNS in Greenville, South Carolina WFXR in Roanoke, Virginia (as "Fox 21/27") KXRM-TV in Colorado Springs, Colorado KQDS-TV in Duluth, Minnesota WBOC-DT2 in Salisbury, Maryland
Other uses: Fox 21 Television Studios, a unit of 20th Television