CIRS may refer to:
CIRS (AM), a Canadian radio station Center for International and Regional Studies, an educational institution in Qatar Centre for Interactive Research on Sustainability, a building at the University of British Columbia Chinmaya International Residential School, a private boarding school near Coimbatore, India Composite Infrared Spectrometer, an instrument in the Cassini-Huygens spacecraft Interest rate swap, an interest rate derivative Chronic inflammatory response syndrome, an illness caused by immune system dysregulation.