S72 may refer to:
Aviation Blériot-SPAD S.72, a French biplane trainer Savoia-Marchetti S.72, an Italian transport monoplane Sikorsky S-72, an American experimental compound helicopter St. Maries Municipal Airport, in Benewah County, Idaho, United States
Other uses , a submarine of the Royal Canadian Navy S72, a postcode district for Barnsley, England