S22 may refer to:
Aviation Hermiston Municipal Airport, in Umatilla County, Oregon, United States Letov Š-22, a prototype Czechoslovak fighter SIAI S.22, an Italian racing flying boat Sikorsky S-22, a Russian trainer
Rail and transit S22 (RER Vaud), an S-Bahn line in Switzerland S20 (St. Gallen S-Bahn), a St. Gallen S-Bahn rush-hour service, Switzerland S22 (ZVV), a former Zurich S-Bahn line, Switzerland Kozawa Station, in Kyōwa, Hokkaidō, Japan Shōji Station (Osaka, Osaka), in Japan
Roads Expressway S22 (Poland) County Route S22 (California), United States
Submarines
, of the Royal Navy , of the Indian Navy , of the Indian Navy , of the United States Navy
Other uses British NVC community S22, a swamps and tall-herb fens community in the British National Vegetation Classification system Karry S22, a Chinese MPV S22: Do not breathe dust, a safety phrase Samsung Galaxy S22, a series of smartphones Sisu S-22, a Finnish lorry