HLA-B (alpha)-β2MG with bound peptide major histocompatibility complex (human), class I, B44 Alleles B*4401, 4402, 4403 . . Structure (See HLA-B) Shared data Locus chr.6 6p21.31 HLA-B44 (B44) is an HLA-B serotype. The serotype identifies the B*44 gene-allele protein products of HLA-B.
B44 is a split antigen of the broad antigen B12, and is a sister type of B45.
Serotype + Serotypes B44, B12, and B45 recognition of the HLA B*44 gene productsderived from IMGT/HLA B*44 B44 B12 B45 Sample allele % % % size (N) 4402 98 6959 4403 94 2854 4404 65 42 4405 92 130 4406 44 9 B*4401 was shown to be B*4402 after errors corrected. Alleles link-out to IMGT/HLA Database at EBI
Alleles
Disease HLA-B44 increases recurrent sinopulmonary infections. Protective effects: HLA-B44 appears to be protective against autoimmune lymphoproliferative syndrome in patients with C95 defect (ALPS type Ia). B44 may be a cofactor in ankylosing spondylitis
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