Palladino is an Italian surname. Notable people with the surname include:
Adriano Palladino (1610–1680), Italian painter of the Baroque era Aleksa Palladino (born 1980), American actress and singer Amy Sherman-Palladino (born 1966), American television writer and producer Daniel Palladino, American television writer and producer Eddie Palladino (born 1958), American basketball announcer for the Boston Celtics Emma Palladino (1861–1922), Italian ballerina Erik Palladino (born 1968), American actor Eusapia Palladino (1854–1918), Italian spiritualist and medium Jack Palladino (1944–2021), American private investigator hired by the Bill Clinton presidential election committee Leandro Palladino (born 1976), Argentine–Italian basketball player Pino Palladino (born 1957), Welsh bassist and record producer Raffaele Palladino (born 1984), Italian football player Robert Palladino (1932–2016), American academic Tony Palladino (born 1983), English cricketer Tony Palladino (1930–2014), American graphic designer
See also Paladino (disambiguation)