Henry Radclyffe or Radcliffe may refer to:

Henry Radclyffe, 2nd Earl of Sussex (1507–1557), son of Robert Radclyffe, 1st Earl of Sussex and Elizabeth Stafford, Countess of Sussex Henry Radclyffe, 4th Earl of Sussex (c. 1530–1593), English peer

See also Harry Radcliffe, Church of England archdeacon