LRN may refer to:

Laboratory Response Network, a collaborative effort of the U.S. Centers for Disease Control and Prevention and the Association of Public Health Laboratories Land Rights News, the longest-running Aboriginal Australian newspaper, published by the Central and Northern Land Councils Lateral reticular nucleus, a nucleus of the medulla oblongata involved with co-ordinating baroreceptor signals to control arterial blood pressure Lead round nose, a type of bullet Legislative route number, a designation for a highway defined by laws passed in a state legislature Location Routing Number, a ten digit phone number used to route phone calls between two telephone exchanges LORAN, a terrestrial radio navigation system originally known as LRN for Loomis Radio Navigation LRN (company), an ethics compliance and education company Luminous red nova, a stellar explosion thought to be caused by the merger of two stars