Isse or ISSE may refer to:
Places Isse, village and commune in north-eastern France Issé, village and commune in north-western France
Computing Information Systems Security Engineering Internet Streaming SIMD Extensions, an SIMD instruction set extension to the x86 architecture by Intel introduced in 1999 Integer Streaming SIMD Extensions, an informal name for MMX extensions associated with 3DNow! extensions
Other uses Issé (opera), by André Cardinal Destouches International Secondary School Eindhoven, a school in the Netherlands International Students for Social Equality Hirsi Magan Isse (1935–2008), scholar and a leading figure of the Somali Revolution