M83 or M-83 may refer to:
Astronomy Messier 83, a spiral galaxy in the constellation Hydra M83 Group, a group of galaxies centered around Messier 83 Military M-83, a Soviet M-class submarine M83 smoke grenade M83 submunition, a US copy of the German Butterfly Bomb of World War II; used in the M29 cluster bomb Music M83 (band), an electronic band named after the galaxy of the same name M83 (album), the debut album of the M83 music group Roads and routes M-83 (Michigan highway), a state highway in Michigan