B59 or B-59 may refer to:
B-59 military hardware: Boeing XB-59, American aircraft model Soviet submarine B-59, a submarine B59: European highways: Bundesstraße 59, in the German Bundesstraße system Eisenstädter Straße in the Austrian Landesstraße system Volvo B59 Swedish-market bus chassis HLA-B59, serotype re Human Leucocyte Antigen B59, chess variation arising from 5...Nc6 in Sicilian Defence Barnard 59, AKA Pipe Nebula