William Brooke may refer to:
William Brooke, 10th Baron Cobham (1527–1597), English peer and MP for Hythe and Rochester William Brooke (1565–1597), English MP for Rochester and Kent. Son of above. Killed in duel. William Brooke (MP, died 1643) (1598–1643), English soldier and politician William Henry Brooke (1772–1860), English artist Willie Brooke (1895–1939), trade union administrator and politician Will Brooke, Chief of Staff to Senator Burns Will Brooke (businessman) (born 1957), Alabama businessman and political candidate
See also William Brooks (disambiguation) William Brooke O'Shaughnessy (1808–1889), Irish physician William Broke, English academic administrator