SMRT may refer to:
Medicine Silencing mediator for retinoid and thyroid-hormone receptor Single Molecule Real Time Sequencing, a parallelized DNA sequencing by synthesis technology
Transport Santa Maria Regional Transit, a local bus system in California, USA Scenic Mississippi Regional Transit, a regional bus system in Wisconsin, USA Mass Rapid Transit (Singapore), a Mass Rapid Transit metro system in Singapore Southern Maryland Rapid Transit, a proposed American light-rail system
Companies Seoul Metropolitan Rapid Transit Corporation, a South Korean subway operator SMRT Corporation, a Singaporean public transport operator SMRT Trains, the rail subsidiary of said operator SMRT Buses, the bus subsidiary
Other uses St Mary Redcliffe and Temple School, a school located at Redcliffe, Bristol Thomas J. Smrt (born 1928), American inventor Homer Simpson's spelling of smart in The Simpsons episode "Homer Goes to College"