Sampedro is a surname, and may refer to:
Drama Guadalupe Muñoz Sampedro (1896–1975) Spanish film actress Matilde Muñoz Sampedro (1900–1969), Spanish film actress Mercedes Muñoz Sampedro (1896–1979), Spanish stage and film actress Sports Amanda Sampedro (born 1993), Spanish footballer Luis César Sampedro (born 1966), Spanish footballer Omar Sampedro (born 1985), Spanish footballer Other uses Alfonso de Bourbon Sampedro (1932–2012), Swiss-American eccentric Edelmira Sampedro y Robato (1906–1994), Countess of Covadonga Frank "Poncho" Sampedro (born 1949), American musician José Luis Sampedro (1917–2013), Spanish economist and novelist Juan José Segura-Sampedro (born 1985), Spanish surgeon and researcher Lorenia Valles Sampedro (born 1976), Mexican politician Melchor García Sampedro (1821–1858), Spanish Dominican missionary and saint Ramón Sampedro (1943–1998), Spanish fisherman who fought for right of assisted suicide Tomás García Sampedro (1860–1937), Spanish painter