East Main Street Historic District, or variations with Residential or Commercial, may refer to:
Batesville East Main Historic District, Batesville, AR, listed on the NRHP in Arkansas East Main Street Historic District (Bridgeport, Connecticut), listed on the NRHP in Connecticut East Main Street-Johnson Street Historic District, Hogansville, GA, listed on the NRHP in Georgia East Main Street Residential Historic District (Lumpkin, Georgia), listed on the NRHP in Georgia East Main Street Residential District (Marshallville, Georgia), listed on the NRHP in Georgia East Main Street Commercial Historic District (Statesboro, Georgia), listed on the NRHP in Georgia East Main Street-Glen Miller Park Historic District, Richmond, IN, listed on the NRHP in Indiana Upper East Main Street District, Bowling Green, KY, listed on the NRHP in Kentucky East Main Street Historic District (Danville, Kentucky), listed on the NRHP in Kentucky East Main Street Historic District (Wilmore, Kentucky), listed on the NRHP in Kentucky East Main Street Historic District (New Iberia, Louisiana), listed on the NRHP in Louisiana East Main Street Historic District (Searsport, Maine), listed on the NRHP in Maine East Main-High Street Historic District, Greenfield, MA, listed on the NRHP in Massachusetts East Main Street-Cherry Street Historic District, Spencer, MA, listed on the NRHP in Massachusetts East Main-Cherry Street Historic District, Spencer, MA, listed on the NRHP in Massachusetts East Main Street Historic District (Waltham, Massachusetts), listed on the NRHP in Massachusetts East Main Street Historic District (West Point, Mississippi), listed on the NRHP in Mississippi East Main Street Residential Historic District (Miles City, Montana), listed on the NRHP in Montana East Main Street Historic District (Richfield Springs, New York), listed on the NRHP in New York East Main Street Commercial Historic District (Palmyra, New York), listed on the NRHP in New York East Main-Mechanic Streets Historic District, Springville, NY, listed on the NRHP in New York East Main Street Historic District (Westfield, New York), listed on the NRHP in New York East Main Street Historic District (Brevard, North Carolina), listed on the NRHP in North Carolina East Main Street Historic District (Forest City, North Carolina), listed on the NRHP in North Carolina East Main Street Historic District (Hillsboro, Ohio), listed on the NRHP in Ohio East Main Street Historic District (Ravenna, Ohio), listed on the NRHP in Ohio East Main Street Historic District (Chesterfield, South Carolina), listed on the NRHP in South Carolina East Main Street-Douglass Heights Historic District, Union, SC, listed on the NRHP in South Carolina East Main Street and Exchange Street Historic District, Union City, TN, listed on the NRHP in Tennessee East Main Street Historic District (Jackson, Tennessee), listed on the NRHP in Tennessee East Main Street Historic District (Murfreesboro, Tennessee), listed on the NRHP in Tennessee East Main Street Residential Historic District (Cuero, Texas), listed on the NRHP in Texas East Main Street Historic District (Pflugerville, Texas), listed on the NRHP in Travis County, Texas East Main Street Historic District (Christiansburg, Virginia), listed on the NRHP in Virginia
See also Georgetown East Main Street Residential District, Georgetown, KY, listed on the NRHP in Kentucky Main Street Historic District (disambiguation) North Main Street Historic District (disambiguation) South Main Street Historic District (disambiguation) West Main Street Historic District (disambiguation)