Maffei is a surname of Italian origin, derived from Maffeo, an archaic form for 'Matthew'. Notable people with the surname include:
People of Arts and letters Andrea Maffei (1798–1885), Italian poet and librettist Andrea Maffei (architect) (born 1968), Italian architect Cesare Maffei (1805–?), Italian painter Claire Mafféi (1919–2004), French actress Damian Maffei (born 1977), American actor Francesco Maffei (1605–1660), Italian painter Francesco Scipione Maffei (1675–1755), Italian art critic, antiquarian, humanist and author Giovanni Camillo Maffei (), Italian physician and music theorist Paolo Maffei (1926–2009), Italian astrophysicist and author Paolo Alessandro Maffei (1653—1716), Italian antiquarian, humanist and author
People in religion Antonio Maffei da Volterra (1450–1478), Italian clergyman and member of the Pazzi Conspiracy Antonio Maffei (died 1482), Italian Roman Catholic prelate Ascanio Maffei (died 1659), Italian Roman Catholic prelate Bernardino Maffei (1514–1553), Italian Roman Catholic cardinal Giovanni Pietro Maffei (1533–1603), Italian Jesuit and writer Giuliano Maffei (died 1510), Italian Roman Catholic prelate Marcantonio Maffei (1521–1583), Italian Roman Catholic cardinal Orazio Maffei (1580–1609), Italian Roman Catholic cardinal Raffaele Maffei (1451–1522), Italian humanist, historian and theologian
People in sports Arturo Maffei (1909–2006), Italian long jumper and footballer Alberto Maffei (born 1995), Italian snowboarder Cecilia Maffei (born 1984), Italian speed skater Claudio Maffei (born 1999), Italian footballer Giuseppe Maffei (born 1974), Italian runner Ivano Maffei (born 1958), Italian cyclist Leonard Maffei (died 1989), Italian-American cyclist Michele Maffei (born 1946), Italian fencer
Others Alessandro Maffei (1662–1730), Bavarian general Blanca Renée Arrillaga Oronoz de Maffei, known as Blanca Renée Arrillaga (1917–2011), Uruguayan chemist, botanist and agrostologist Clara Maffei (1814–1886), Italian socialite and salon hostess Dan Maffei (born 1968), American politician Greg Maffei (born 1960), American businessman Joseph Anton von Maffei (1790–1870), German industrialist
See also Maffeis Maffey Mattei Mazzei