Ghukasyan () ) is an Armenian surname, meaning 'son of Ghukas', the Armenian equivalent of Luke. In Russia, Azerbaijan and other countries, some holders of this surname changed the spelling to Gukasov ().
People with the surname include: Andrias Ghukasyan (born 1970), Armenian politician and political analyst Arkadi Ghukasyan (born 1957), second president of the Republic of Artsakh Siranush Ghukasyan (born 1998), Armenian chess master Vardan Ghukasyan (born 1961), Armenian politician
See also Arshak Ter-Gukasov (1819–1881), Yerevan Forces commander of Russia's army during the Russo-Turkish War of 1877–1878 Voroshil Gukasyan (1932–1986), Soviet linguist