James Otis may refer to:
James Otis Sr. (1702–1778), Massachusetts lawyer and public official James Otis Jr. (1725–1783), American revolutionary politician from Massachusetts James Otis (mayor) (1826–1875), mayor of San Francisco, California James Otis (New York politician) (1836–1898), member of the New York State Senate and a society leader during the Gilded Age James C. Otis (1912–1993), Justice of the Minnesota Supreme Court Jim Otis (born 1948), American football player James Otis, pen name of James Otis Kaler (1848–1912), American journalist and children's author