Delfino is a masculine given name and surname. Notable people with the name include:
Surname Alejandro Delfino (born 1962), original name of Alex To, Hong Kong singer and actor Carlos Delfino (born 1982), Argentine professional basketball player Daniel Delfino (born 1970), Argentine former professional association football player Frank Delfino (1911–1997), American actor Frank Delfino, fictional character played by Charlie Weber (List of How to Get Away with Murder characters) Giuseppe Delfino (1921–1999), Italian fencer Jean-Paul Delfino (born 1964), French author Jessica Delfino (born 1976), American singer, songwriter and comedian Majandra Delfino (born 1981), Venezuelan-born American actress and singer Mariano Delfino (born 1977), Argentine former professional tennis player Mike Delfino, fictional character on Desperate Housewives
Given name Delfino Borroni (1898–2008), Italian supercentenarian Delfino Codazzi (1824–1873), Italian mathematician