Margaret II may refer to:
Margaret II of Flanders (1202–1280), Countess of Flanders and Hainaut, aka Margaret of Constantinople Margaret II of Hainaut (1311–1356), Countess of Hainaut and countess of Holland Margaret II, Countess Palatine of Burgundy (1350–1405), Countess of Flanders & Artois; Countess Palatine of Burgundy; Duchess of Burgundy Margrethe II (born 1940), Queen-regnant of Denmark (1972-2024)