PKU may refer to:
Phenylketonuria, a genetic disease Peking University (PKU), a public university in Haidian, Beijing, China PKU Resources, a Chinese conglomerate PKU Healthcare, a Chinese pharmaceutical company Pku, an Armenian musical instrument Sultan Syarif Kasim II International Airport (IATA code), in Pekanbaru, Riau, Indonesia Paku language (Indonesia), a language of Kalimantan, Borneo (ISO 639-3 code: pku) Partai Kebangkitan Umat (Ummah Awakening Party); see List of political parties in Indonesia A unit of PASKAU, special forces of Malaysia Panskura Junction railway station (station code: PKU), West Bengal, India