Isshiki (written: 一色) is a Japanese surname. Notable people with the surname include:

, Japanese manga artist , Japanese actress , Japanese samurai and daimyō , Japanese samurai and daimyō

Fictional characters: Akane Isshiki, protagonist of the anime series Vividred Operation Iroha Isshiki, a character in My Teen Romantic Comedy SNAFU Makoto Isshiki, a character in RahXephon Satoshi Isshiki, a character in Food Wars!: Shokugeki no Soma

See also Isshiki clan Isshiki, Aichi, former town in Aichi Prefecture, Japan