Christopoulos () is a Greek surname. Notable people with the surname include:
Anastasios Christopoulos (1805–1854), Greek revolutionary leader Apostolos Christopoulos (born 2003), Greek footballer Athanasios Christopoulos (1772–1847), Greek poet Dimitrios Christopoulos, Greek athlete George Christopoulos (born 1960), Australian association football player Giannis Christopoulos (born 1972), Greek association football coach Spyros Christopoulos (born 1975), Greek footballer Stephanos Christopoulos (born 1876), Greek wrestler Vasileios Christopoulos (born 1951), Greek writer Yannis Christopoulos (born 1974), Greek basketball coach
el:Χριστόπουλος