A neuroectodermal neoplasm is a neoplasm or tumor of the neuroectoderm.Neuroectodermal tumor entry in the public domain NCI Dictionary of Cancer Terms They are most commonly tumors in the central or peripheral nervous system.

Tumors exhibiting neuroectodermal differentiation are classified into two main groups: Group I tumors/neoplasms: neuroendocrine carcinomas. These show predominantly epithelial differentiation. They include pituitary adenoma and carcinoid tumor Group II tumors/neoplasms: nonepithelial neuroectodermal neoplasms. These are predominantly neural in origin. They include melanoma, olfactory neuroblastoma, and Ewing's sarcoma.

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