DXS may refer to:
Department of External Services, a fictional U.S. intelligence agency on the TV show MacGyver Dexus, Australian stock exchange ticker symbol DXS, a web service component formerly known as Get Hot New Stuff in KDE Software Compilation 4 Deep Extragalactic Survey, one of five components of the UKIRT Infrared Deep Sky Survey Diffuse X-ray Spectrometer, instrumentation on the NASA Space Shuttle mission STS-54 DK X Seungkwan, K-pop duo also known as DxS