Tessio is a surname. Notable people with the surname include:
Aldo Tessio (1909–2000), Argentine politician Griselda Tessio (born 1946), Argentine politician, Vice-Governor of Santa Fe province since 2007
Fictional characters: Salvatore Tessio, fictional character in Mario Puzo's novel The Godfather and the film based on it
See also Tessio (Luomo), a single by techno musician Luomo