Swayne is a surname. Notable people with the surname include:
Charles Swayne (1842–1907), American district judge Charles Richard Swayne (1843–1921), first Resident Commissioner of the Gilbert and Ellice Islands, a British protectorate Deborah F. Swayne (born 1952), American statistician Desmond Swayne (born 1956), British politician Eric John Eagles Swayne (1863-1929), British Army officer and colonial administrator Geraldine Swayne (born 1965), British painter and filmmaker Giles Swayne (born 1946), British composer Harald George Carlos Swayne (1860-1940), British Army officer explorer, naturalist, big game hunter and writer, brother of Eric Swayne Harry Swayne (born 1965), American National Football League player Harry Swayne (cricketer) (1869–1911), English cricketer John Swayne (1890–1964), Second World War British Army lieutenant-general Joseph Griffiths Swayne (1819–1903), English obstetric physician who investigated cholera Kevin Swayne (born 1975), American football player Noah Haynes Swayne (1804–1884), American jurist and politician, a United States Supreme Court justice Steve Swayne, music professor Sylvia Swayne (born 1997), American politician Thomas Swayne, 18th century cricketer Wager Swayne (1834-1902), American Civil War Union Army major general awarded the Medal of Honor, son of Noah Haynes Swayne William Swayne (1862–1941), Anglican bishop and author William Marshall Swayne (1828–1918), American sculptor William Swayne (MP), Member of Parliament for Chippenham (UK Parliament constituency) in 1589