Andy or Andrew O'Brien may refer to:
Andrew O'Brien (politician) (fl. 1990s-2010s), US Department of State official Andrew O'Brien (rugby) (1897–1969), New Zealand rugby footballer Andy O'Brien (footballer) (born 1979), Irish footballer Andy O'Brien (hurler) (born 1988), Irish hurler Andy O'Brien (journalist) (1910–1987), Canadian sports journalist Andy O'Brien (politician) (1915–2006), Irish Fine Gael senator Andy O'Brien (executive) (2026-current), ConocoPhillips Company President and CEO
Fictional Andy O'Brien (EastEnders), a character in EastEnders