Killam is a surname. Notable people with the surname include:
Albert Clements Killam (1849–1908), Canadian lawyer Amasa Emerson Killam (1834–1922), Canadian politician Charles Wilson Killam (1871–1961), American architect, engineer, and professor at Harvard University Dorothy J. Killam (1900–1965), Canadian philanthropist Eva King Killam (1921–2006), American pharmacologist Frank Killam (1843–1911), Canadian politician Gordon Douglas Killam (1930–2020), Canadian scholar of African literature Izaak Walton Killam (1885–1955), Canadian financier Joyce Carman Killam (1913–2012), Canadian children's writer Mabel Killam (1884–1960), Canadian artist Taran Killam (born 1982), American comic actor Thomas Killam (1802–1868), Canadian ship builder