William Grayson (1736–1790) was a U.S. senator from Virginia.
William Grayson may also refer to:
William Grayson Carter (died 1849), American politician from Kentucky and grandson of the senator William J. Grayson (1788–1863), U.S. representative from South Carolina William W. Grayson (1876-1941), American soldier, known for firing the shot that started the Philippine–American War SS William Grayson, a Liberty ship, named for the senator See also Will Grayson, Will Grayson, a novel by John Green and David Levithan William Gray (disambiguation)