Striatin-interacting protein 1 is a protein that is located on chromosome 1 in humans and is encoded by the STRIP1 gene.. STRIP1 is also known as FAM40A.
Characteristics and secondary structure FAM40A has an isoelectric point of 5.92 and a molecular weight of 95,575 daltons.pI/MW Tool It is predicted to have three transmembrane domains, making it a transmembrane protein.Transmembrane domain prediction FAM40A does not contain a signal peptide and is also predicted to bind to DNA, possibly making it a membrane protein in the nuclear membrane.SignalP 3.0 ServerSOSUI System
The secondary structure of FAM40A is predicted to contain twenty-six alpha helices and two beta sheets.Phyre v. 2.0 The 5' untranslated region of FAM40A is predicted to contain one stem-loop and the 3' untranslated region is predicted to contain eight stem-loop structures. Two miRNAs are predicted to bind to two of the stem-loop structures present in the 3' UTR region.miRBase
Homology FAM40A has no paralogs. However, it does have orthologs stretching all the way back to yeast. It has been suggested that FAM40A is a homolog to the yeast gene FAR11, which is involved in the recovery from cell cycle arrest.Yeast Gene FAR11 from Saccharomyces Genome DatabaseNational Center for Biotechnology Information (NCBI) Protein
The following table represents a small selection of orthologs found using searches in BLASTNCBI BLAST: Basic Local Alignment Search Tool and BLAT.BLAT Search Genome This is by no means a comprehensive list, however it does show the vast diversity of species where FAM40A orthologs are found.
Scientific name Common name Accession number (from NCBI ) Sequence length Percent identity Percent Similarity Homo sapiens Human NP_149079 837 - - Pongo abelii Sumatran orangutan XP_002810520 837 99.6% 100% Sus scrofa Pig XP_003125904 837 98.8% 100% Equus caballus Horse XP_001493762 837 98.8% 100% Mus musculus Mouse NP_705791 837 98% 100% Rattus norvegicus Rat XP_001068288 837 97.8% 100% Monodelphis domestica Gray short-tailed opossum XP_001372588 843 95.4% 100% Danio rerio Zebra fish XP_001918929 813 83.4% 98% Canis lupus familiaris Dog From BLAT 812 96.1% 100% Ailuropoda melanoleuca Panda From BLAT 823 $96.2 100% Oryzias latipes Medaka From BLAT 751 78.4% 96% Xenopus (Silurana) tropicalis Western clawed frog NP_001027483 819 86.4% 96% Aedes aegypti Yellow-fever mosquito XP_001658692 829 51.2% 97% Tribolium castaneum Red flour beetle XP_001815164 817 57.4% 97% Hydra magnipapillata Hydra hydrozoan XP_002164866 830 44% 97% Ciona intestinalis Sea squirt XP_002130558 867 46.4% 97% Pediculus humanus corporis Human lice XP_002425964 808 52.7% 97% Nasonia vitripennis Jewel wasp XP_001603859 802 52.7% 97% Drosophila erecta Fruit fly XP_001971743 882 45.2% 97% Saccharomyces cerevisiae Bakers yeast NP_014272 953 18.9% 97%
Expression FAM40A is expressed in high levels during the blastocyst, eight-cell stage, and fetal stages of development. FAM40A has also been shown to be expressed in high levels in the mammary glands, brain, thymus, mouth and the testes. It has also been shown to be expressed in high levels in mammary gland tumors, leukemia cells, and germ cell tumors.
Transcription Regulation FAM40A is predicted to have a promoter region 789 base pairs upstream of the start of transcription. The SOX transcription factors are predicted to bind to the promoter region of the FAM40A gene, possibly indicating a role in sex determination.
Interactions FAM40A has been shown to interact with STK26, STRN, PDCD10, TRAF3IP3, STRN3, PPP2R1A, MOBKL3, CTTNBP2NL, STK24 and PPP2CA.
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Further reading