Transmembrane protein 222 is a protein that in humans is encoded by the TMEM222 gene. One notable feature of the protein encoded by this gene is the presence of three predicted transmembrane domains.TMHMM The TMEM222 protein is predicted to most likely localize to the secretory vesicles.k-NN

Gene Features

TMEM222 has a domain of unknown function (DUF778).NCBI (National Center for Biotechnology information) Aliases of this gene include DKFZP564D0478, RP11-4K3__A.4, C1orf160, and MGC111002.Gene Cards Accession NM_032125.2, the longest coding sequence (1629 bp), encodes a protein of 208 amino acid residues (23230 daltons), which is considered the consensus coding sequence (CCDS297.2).Uniprot There are two isoforms of the protein encoded by this gene. They are similar except the second (Q9H0R3-2) is lacking the first 96 amino acid residues that are present in the first (Q9H0R3-1).Uniprot

Gene Expression

ACEVIEW has labeled TMEM222 as highly expressed with 3.8 times more expression than the average gene in the database.ACEVIEW There is expression evidence from 166 tissues including brain, lung, colon, kidney, and placenta.

Homology

Orthologs and distant homologs of the human TMEM222 have been identified throughout Eukaryota especially in plants and animals. No paralogs of this gene have been found in the human genome.BLAST Genus/Species Common name Accession number Length Similarity Identity Rattus norvegicus Rat NP_001107252.1 208aa 99% 96% Canis familiaris Dog XP_852505.1 208aa 98% 96% Mus musculus Mouse NP_079943.2 208aa 96% 95% Sus scrofa Pig XP_003127773.1 208aa 97% 94% Equus caballus Horse XP_001917747.1 207aa 94% 93% Gallus gallus Chicken XP_417729.1 182aa 90% 85% Danio rerio Zebrafish NP_001013334.1 174aa 83% 71% Anopheles gambiae Mosquito XP_320483.3 197aa 66% 53% Drosophila melanogaster Fruit Fly NP_723362.1 196aa 74% 61% Caenorhabditis elegans Nematode NP_494762.2 168aa 72% 55% Phytophthora infestans Late Blight XP_002902629.1 186aa 59% 48% Zea mays Corn NP_001144071.1 233aa 61% 44% Oryza sativa Rice NP_001051577.1 204aa 61% 43% Arabidopsis thaliana Thall cress NP_190673.1 231aa 55% 36% Homo sapiens Human NP_115501.2 208 - -

Distant Homolog

A distant homolog of TMEM222, RTH (RTE1-Homolog), is a homolog of RTE1 (Reversion-to-Ethylene Perception 1), which is known to induce conformational changes in ETR1 (Ethylene receptor 1) that result in negative regulation corresponding with loss of ethylene perception.

Protein Interactions

Evidence from yeast two-hybrid screening exists for two protein interactions with this gene. One is a serine protease (PRSS23) that has been identified to be involved in mouse ovulation and is excreted into the extracellular matrix. The other protein is an ab-hydrolase (HLA-B associated transcript 5) that is integral to the membrane, and its corresponding gene is located in the genome near Tumor Necrosis Factor (TNF)-alpha and TNF-beta.

References

Further reading