Guanylyl cyclase-activating protein 2 is an enzyme that in humans is encoded by the GUCA1B gene. Alternative names: Guanylate cyclase activator 1B Retinal guanylyl cyclase activator protein p24
Biological Role Guanylyl cyclase-activating protein 2 is proposed to play a role in dark adaptation. Under scotopic conditions, calcium ions bind to three putative EF-hand calcium binding motifs which reduces the protein's ability to stimulate guanylyl cyclase. This contributes to the maintained responsiveness of rod photoreceptors through hyperpolarizing them during sustained darkness.
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External links GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview