Isonville is an unincorporated community in Elliott County, Kentucky, United States. It lies along Routes 32 and 486 east of the city of Sandy Hook, the county seat of Elliott County.Rand McNally. The Road Atlas '06. Chicago: Rand McNally, 2006, p. 43. Its elevation is 709 feet (216 m)., Geographic Names Information System, 1979-09-20. Accessed 2008-01-03. It has a post office with the ZIP code 41149.USPS – Cities by ZIP Code
A post office was established in the community in 1866 and named for Archibald Ison, an early settler from Virginia.
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