Ephron is a Jewish surname. Notable people with the surname include:
Ephron (biblical figure), Hittite who sold a cave to Abraham according to the Bible A family of American writers: Henry Ephron (1911–1992), father Phoebe Ephron (1914–1971), mother Amy Ephron (born 1952), daughter Delia Ephron (born 1944), daughter Hallie Ephron (born 1948), daughter, sometimes writes as G. H. Ephron Nora Ephron (1941–2012), daughter Theron Ephron Catlin (1878–1960), American politician from Missouri
See also Efron