William Culpepper may refer to:
William T. Culpepper III, (born 1947) American politician William Colepeper (died 1726), English politician and poet Sir William Culpeper, 1st Baronet of Preston Hall (1588–1651), of the Culpeper baronets Sir William Culpeper, 1st Baronet of Wakehurst (died 1651), of the Culpeper baronets Sir William Culpeper, 4th Baronet (1668–1740), of the Culpeper baronets