Antonopoulos () is a Greek surname with the female version being Antonopoulou (). The name is derived from the root name Antonius. Among others, it is the surname of:

Anastasios Antonopoulos (1893–???), Greek wrestler Andreas Antonopoulos (born 1972), Greek British bitcoin advocate and security expert Antonios Antonopoulos (1805–1887), Greek politician Apostolos Antonopoulos (born 1983), Greek swimmer Constantinos Antonopoulos, Greek businessman Filonas Antonopoulos, Greek footballer (AEK Athens F.C. president) Ioannis Antonopoulos (1810–1882), Greek politician Seven Antonopoulos (born 1974), American rock drummer

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