Sialin

Sialin, also known as H(+)/nitrate cotransporter and H(+)/sialic acid cotransporter, is a protein which in humans is encoded by the SLC17A5 gene.

In a 2001 study of the experimental group-B-streptococcal polysaccharide CM101, the human SLC17A5 gene product was called HP59 (with a sheep sequence called SP55).

Clinical significance

A deficiency of this protein causes Salla disease. and Infantile Sialic Acid Storage Disease (ISSD).

The gene for HP59 contains, entirely within its coding region, the Sialin Gene SLC17A5. Member 5, also known as SLC17A5 or sialin is a lysosomal membrane sialic acid transport protein which in humans is encoded by the SLC17A5 gene on Chromosome 6"Entrez Gene: SLC17A5 solute carrier family 17 (anion/sugar transporter), member 5"

See also Solute carrier family

References

Further reading