PEA15

Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.

PEA15 is a death effector domain (DED)–containing protein predominantly expressed in the central nervous system, particularly in astrocytes.

PEA-15 promotes autophagy in glioma cells in a JNK-dependent manner.

Interactions

PEA15 has been shown to interact with: Caspase 8, FADD, and MAPK1, Phospholipase D1, and RPS6KA3.

References

Further reading