Dopachrome tautomerase is an enzyme that in humans is encoded by the gene DCT. Its expression is regulated by the microphthalmia-associated transcription factor (MITF). Dopachrome tautomerase is induced by blue light, and is involved in the production of melanin. Pathogenic mutations in the DCT gene have been associated with oculocutaneous albinism, where low levels of pigment are produced by the skin, hair, and eyes. The type linked to DCT has relatively mild symptoms and is called Oculocutaneous Albinism, Type VIII.
Alternative names include dopachrome delta-isomerase and tyrosinase-related protein 2.
See also Tyrosinase-related protein 1 (TYRP1) Dopachrome, a cyclization product of L-DOPA and is an intermediate in the biosynthesis of melanin.
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